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10.1038/s41418-020-00644-4 224 WangL.LiuY.DuT.YangH.LeiL.GuoM.et al (2020b)

Secondly, mitochondria regulate redox balance, with balanced ROS production maintaining ECM integrity by modulating matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), while excessive mitochondrial reactive oxygen species (ROS) can lead to collagen fragmentation and elastin degradation [13,14,15]

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